The Effect of Methylphenidate on Motor Learning in Stroke Patients
Status and phase
Conditions
Treatments
Details and patient eligibility
About
The purpose of the study is to determine whether methylphenidate facilitates so called short-term plasticity as measures with transcranial magnetic stimulation, in patients with stroke.
Full description
Stroke patients are to be examined with transcranial magnetic stimulation (TMS) before and after a short training session. TMS will be used to demonstrate changes in cortical excitability (motor threshold) and intracortical inhibition and facilitation. The effect of methylphenidate on baseline TMS measures will be evaluated as well as the effect on training induced changes in TMS measures (by comparing baseline and posttraining measures). The patients will be trained on two separate occasions, to compare the effect of Methylphenidate to placebo.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Less than two months after first stroke.
- Moderate to light hand paralysis
- Measurable MEP in the abductor pollicis brevis muscle
- Able to read and understand the written information
- Signed informed consent
Exclusion criteria
- Epilepsy
- Glaucoma
- Hyperthyroidism
- Cardiac arrythmia
- Known heart disease or angina.
- Metal implants
- Pacemaker
- Pregnancy
- Diastolic BP>100 mmHg
- In treatment with MAO-inhibitor, SSRIs og Ritalin
Trial design
Primary purpose
Allocation
Interventional model
Masking
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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