The Effect of Midazolam Premedication on Copeptine Concentration in Blood

Medical University of Warsaw

Status and phase: Completed; Phase 4

Conditions: Preanesthetic Medication; Copeptin

Treatments: Other: Placebo Oral Tablet; Drug: Midazolam Oral Tablet

Study type: Interventional

Funder types: Other

Identifiers

NCT03474939

MIDPRECOP

Details and patient eligibility

About

The study aim is to assess whether premedication with midazolam prior to surgery affects copeptin concentration in blood.

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients scheduled for elective surgery
• Patients with no chronić illness and considered ASA 1 by anesthesiologist
• Patients with mild and controlled chronic illness considered ASA 2 by anesthesiologist

Exclusion criteria

• Patient refusal
• Chronic illness requiring intense treatment or uncontrolled illness (ASA 3 or more)

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups, including a placebo group

MIDAZOLAM

Active Comparator group

Description:

Patients receive midazolam 7,5mg night before and 60 minutes prior to surgery as part of preanesthetic medication

Treatment:

Drug: Midazolam Oral Tablet

PLACEBO

Placebo Comparator group

Description:

Patients receive 1000mg Glucose tablets night before and 60 minutes prior to surgery during premedication

Treatment:

Other: Placebo Oral Tablet