The Effect of Mifepristone on the Expression of Cervical Prostaglandin EP3 Receptors

University of Southern California

Status: Terminated

Conditions: Cervical Prostaglandin EP3 Receptors; Pregnancy

Treatments: Drug: Mifepristone; Other: Non-treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT01224509

EP3 receptors

Details and patient eligibility

About

The purpose of this study is to determine the effect of mifepristone on the expression of three cervical EP3 receptor isoforms (EP3-2, EP3-3 and EP3-6) in pregnant women ≤63 days gestational age.

Enrollment: 18 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• good general health
• ≥18 years old
• seeking termination of a viable intrauterine pregnancy of ≤63 days, without any evidence of a threatened or spontaneous abortion

Exclusion criteria

• medical problems
• confirmed or suspected ectopic pregnancy
• having taken medications in the seven days prior to enrollment that would affect PG synthesis or metabolism of mifepristone

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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18 participants in 2 patient groups

Mifepristone

Experimental group

Treatment:

Drug: Mifepristone

Non-treatment

Active Comparator group

Treatment:

Other: Non-treatment