Effect of Mild Sedation and Analgesia on Radial Artery Cannulation in Novice Residents

Affiliated Hospital of Jiaxing University

Status: Completed

Conditions: Sedation and Analgesia

Treatments: Drug: mild sedation and analgesia; Drug: control

Study type: Interventional

Funder types: Other

Identifiers

NCT05863455

2023-KY-297

Details and patient eligibility

About

The aim of this study is to conduct a prospective, single-center randomized controlled study to investigate the effect of mild midazolam combined with sufentanil on radial artery cannulation in novice operators.

Full description

outcome: patients discomfort，visual analogue scale，First-attempt success rate，the success rate of radial artery cannulation within 10 minutes, Complication rate

Enrollment: 108 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who required arterial cannulation for continuous blood pressure monitoring
• Aged >20years
• ASA physical status of 1-3
• BMI 18-28kg/m2
• All patients agreed to participate in this study at the time of recruitment and signed an informed consent form.

Exclusion criteria

• a positive Allen's test
• infection at the puncture site
• coagulation disorders; arterial diseases (such as Raynaud's disease or thromboangiitis obliterans)
• use of vasoactive drugs within 30 minutes before measurement during the study
• patients with arterial abnormalities and bends; hemorrhagic shock
• arterial atherosclerosis; radial artery puncture within the past 30 days
• chronic use of opioid or benzodiazepine drugs
• and known allergies or adverse reactions to benzodiazepines or opioids.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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108 participants in 2 patient groups

mild sedation and analgesia

Experimental group

Description:

Intravenous injection of 0.1ug/kg sufentanil and 0.03mg/kg midazolam for sedation and analgesia before radial artery cannulation.

Treatment:

Drug: mild sedation and analgesia

control

Active Comparator group

Description:

Intravenous injection of an equivalent volume of saline before radial artery cannulation.

Treatment:

Drug: control