The Effect of Mild Weight Loss on Circulating Metabolite Profiles
Status
Conditions
Treatments
Details and patient eligibility
About
To determine whether low calorie diet (LCD)-induced weight reduction caused changes in plasma metabolites and metabolic traits from baseline.
Full description
Over a 12-week clinical intervention period, a randomized, controlled study was carried out; overweight subjects consumed a LCD (approximately 300kcal/d deficit, n=47) or a weight-maintenance diet (control, n=50) were included for analyzing plasma samples and metabolites using an ultra-performance liquid chromatography and mass spectrometry (UPLC-LTQ/Orbitrap MS).
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Able to give informed consent
- 20-65 years old
- Males and females
- Overweight (25.0 kg/m²≤ Body mass index <30 kg/m²)
- Nondiabetic (Fasting glucose <126 mg/dL)
Exclusion criteria
- Unstable body weight (body weight change >1 kg within 3 months before screening)
- Consumption of medication that affects body weight or energy expenditure
- Pregnancy or breast-feeding
- Hypertension, type 2 diabetes, cardiovascular disease, cerebrovascular disease, or thyroid disease
- Liver disease, kidney disease, or gastrointestinal disease
- Acute or chronic infections
- Any acute or chronic disease requiring treatment
Trial design
Primary purpose
Allocation
Interventional model
Masking
100 participants in 2 patient groups, including a placebo group
Trial contacts and locations
Loading...
Data sourced from clinicaltrials.gov
Clinical trials
Research sites
Resources
Legal