The Effect of Modafinil on Affective and Cognitive Processing

University of Electronic Science and Technology of China

Status: Unknown

Conditions: Healthy

Treatments: Drug: Modafinil Oral Tablet; Drug: Placebo Oral Tablet

Study type: Interventional

Funder types: Other

Identifiers

NCT03426202

UESTC-neuSCAN-49

Details and patient eligibility

About

The study aims to examine whether a single dose of modafinil (200mg, p.o.) can affect feedback-based learning and interference processing in healthy male subjects.

Full description

Based on previous animal and human research suggesting a catecholamine-mediated, potentially pro-cognitive, mechanism of action of modafinil, the present study seeks to explore effects of modafinil on feedback-based learning and interference processing in healthy subjects. To this end, the present randomized double-blind, between-subject, placebo-controlled pharmaco-fMRI experiment plans to determine the behavioral and neural effects of a single dose of p.o.modafinil (200mg) versus placebo on validated feedback-based learning and emotional/non-emotional cognitive conflict paradigms. To control for potential effects of pre-medication personality traits as well as effects of modafinil on subjective task performance, subjects will be administered pre-treatment assessing relevant personality traits and post-treatment assessments of meta-cognitive confidence estimation.

Enrollment: 60 estimated patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy subjects without past or current psychiatric or neurological disorders
• Non-smokers
• Right-handedness

Exclusion criteria

• Medical or psychiatric illness
• Allergy against medications or general strong allergies
• Sleep disorders
• High blood pressure, general cardio-vascular alterations
• History of head injury
• Visual or motor impairments

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

modafinil group

Experimental group

Description:

a single dose of p.o. modafinil (200mg)

Treatment:

Drug: Modafinil Oral Tablet

placebo group

Experimental group

Description:

a single dose of p.o. placebo (200mg)

Treatment:

Drug: Placebo Oral Tablet