The Effect of Morphine on Prasugrel Absorption in STEMI Patients

NHS Foundation Trust

Status and phase: Completed; Phase 4

Conditions: Cardiovascular Disease

Treatments: Drug: saline; Drug: morphine

Study type: Interventional

Funder types: Other

Identifiers

NCT01536964

STH16207

2011-003320-12 (EudraCT Number)

Details and patient eligibility

About

Heart Attacks are a major cause of death in this country. When patients have a heart attack, they are treated with anti-clotting drugs, one of which is a drug called Prasugrel. It is important that Prasugrel starts to work as quickly as possible following a heart attack. As many patients who have a heart attack experience excruciating pain, they are often given morphine (a strong painkiller) by the Ambulance crew. We think that morphine may affect how Prasugrel is absorbed from the stomach and may delay how quickly it starts to work. We intend to study the effect of morphine on the absorption of Prasugrel.

Enrollment: 12 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• >18 years of age and willing and able to provide informed consent
• Admission to hospital with a STEMI >12 months prior to recruitment
• Previous prasugrel and morphine use with no adverse effect

Exclusion criteria

• Active respiratory disorder, resting oxygen saturation < 95% or decompensated congestive cardiac failure
• Current use of anti-platelet or anti-coagulant drugs apart from aspirin 75 mg daily, or receipt of any dose of clopidogrel, prasugrel or ticagrelor in the last 2 weeks
• Current use of opiate analgesia

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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12 participants in 2 patient groups, including a placebo group

Morphine

Experimental group

Description:

the effect of morphine on prasugrel absorption will be tested

Treatment:

Drug: morphine

Saline

Placebo Comparator group

Treatment:

Drug: saline