The Effect of Motilin on the Frequency and Amount of Food Intake

U

Universitaire Ziekenhuizen KU Leuven

Status and phase

Unknown
Phase 4

Conditions

Healthy
Obesity

Treatments

Drug: Saline
Drug: Erythromycin

Study type

Interventional

Funder types

Other

Identifiers

NCT03024879
MotilinAndFoodIntake

Details and patient eligibility

About

In this study, the investigators aimed at evaluating the role of motilin in the regulation of food intake. Motilin, a gastrointestinal hormone, is a hunger signal in healthy volunteers and is significantly increased in obese patients. Its role in food intake regulation might contribute to the pathogenesis of obesity.

Enrollment

15 estimated patients

Sex

All

Ages

18 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • BMI < 30 kg/m² for lean volunteers
  • BMI > 30 kg/m² for obese volunteers
  • Subject is capable and willing to give informed consent
  • Female volunteers of child bearing potential must use oral, injected or implanted hormonal methods of contraception

Exclusion criteria

  • Female volunteer is pregnant or breastfeeding
  • GI diseases, major abdominal surgery
  • Major psychiatric illnesses
  • Volunteers that use drugs affecting the GI tract or the central nervous system
  • Volunteers suffering from endocrine diseases such as diabetes, Cushing's disease, Addison's disease, hypothalamic tumor
  • Volunteers that have undergone surgical procedure for weight loss

Trial design

15 participants in 2 patient groups, including a placebo group

Erythromycin
Active Comparator group
Description:
40 mg of erythromycin will be administered intravenously over a period of 20 min in a saline solution of 100 ml
Treatment:
Drug: Erythromycin
Placebo
Placebo Comparator group
Description:
a saline solution of 100 ml will be administered intravenously over a period of 20 min
Treatment:
Drug: Saline

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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