The Effect of Multiple Injection of Platlet-rich Plasma in Chronic Patellar Tendinopathy

Chang Gung Medical Foundation

Status and phase: Unknown; Phase 3; Phase 2

Conditions: Tendinopathy

Treatments: Biological: Platlet-rich plasma

Study type: Interventional

Funder types: Other

Identifiers

NCT03986372

201900117A3

Details and patient eligibility

About

According to previous studies, the effect of PRP to patellar tendinopathy could last longer. However, the type, concentration, time and frequent of injection are still debated。 This study is to understand the effect of multiple injection of platlet-rich plasma in chronic patellar tendinopathy and to analyze the relation between efficacy of PRP and the growth factor in PRP.

Full description

Patellar tendinopathy, also known as jumper's knee，is clinically common characterised by anterior knee pain, activity-related pain、local tenderness over inferior pole of patella. The discomfort can result in decreasing athletic performance and be one of the most challenge for sports medicine doctor.

The patellar tendon suffer from repetitive microtrauma，result in reactive patellar tendinopathy. The overload tendon combining with risk factors of patellar tendinopathy will not recover timely and progress to chronic patellar tendinopathy. Hence, to reverse the progression is our aim.

According to previous studies, several nonsurgical treatment options have been proposed such as medication, eccentric exercise, corticosteroid injection, shockwave and platelet-rich plasma (PRP). Among all the options, the effect of PRP could last longer. However, the type, concentration, time and frequent of injection are still debated。Moreover, there is no study about the relationship between efficacy and the ratio and concentration of growth factor in the PRP.

The aim of this study is to understand (1) The effect of multiple injection of platlet-rich plasma in chronic patellar tendinopathy. (2) The effect of leukocyte-rich PRP in chronic patellar tendinopathy (3) Analyze the relation between efficacy of PRP and the growth factor in PRP.

Enrollment: 60 estimated patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Chronic patellar tendinopathy

Exclusion criteria

1. Corticosteroid injections within 12 months
2. Previous knee surgery
3. Any confounding diagnosis to the knee joint
4. Arthritis
5. Rheumatoid arthritis
6. Diabetes
7. Infections of knee joint
8. NSAIDs in the 10 days before the procedure

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 3 patient groups

PRP injection, once

Experimental group

Description:

PRP injection, once

Treatment:

Biological: Platlet-rich plasma

PRP injection, twice

Experimental group

Description:

PRP injection, twice, 2 weeks apart

Treatment:

Biological: Platlet-rich plasma

PRP injection, 3 times

Experimental group

Description:

PRP injection, 3 times, 2 weeks apart

Treatment:

Biological: Platlet-rich plasma