The Effect of Multiple Medications on the Incidence of Organic Dyspepsia

Air Force Military Medical University of People's Liberation Army

Status: Enrolling

Conditions: Dyspepsia

Study type: Observational

Funder types: Other

Identifiers

NCT05524675

KY20222180-F-2

Details and patient eligibility

About

Dyspepsia is a very common gastrointestinal disease, presented as predominant symptom of upper abdominal pain. Underlying causes for dyspepsia can classified as organic or functional dyspepsia. Some medications (eg. non-steroid anti-inflammatory drugs (NSAIDs)) were associated with higher frequent incidences of organic lesions. Multiple medications showed an increased trend with aging of the population and multimorbidity. Multiple medications were suggested to be strongly relate to adverse drug events (ADEs), adverse drug reactions (ADRs), drug-drug interactions, and drug-disease interactions, which had been reported to lead to higher incidences of some diseases, including fractures, cognitive impairment and malnutrition. However, it was unknown if multiple medications was associated with more incidences of organic dyspepsia.

Enrollment: 500 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. aged ≥18 years old
2. patients who met broad criteria of dyspepsia
3. undergoing upper endoscopy and abdominal ultrasonography within one year.

Exclusion criteria

1. organ failure defined by Marshall standard
2. severe psychiatric illnesses
3. suspected or identified bowel obstruction
4. known malignancy
5. pregnancy or lactation
6. unable to provide consent