The Effect of Multiple-Task Training in Patients With Multiple Sclerosis

Gazi University

Status: Completed

Conditions: Multiple Sclerosis

Treatments: Other: Multi-task training; Other: Single task training

Study type: Interventional

Funder types: Other

Identifiers

NCT03512886

231

Details and patient eligibility

About

The Activities of Daily Living requires the ability to perform multiple activities at the same time, not just the motor or cognitive activity. When many tasks are performed at the same time, the attention capacity is effectively used and attention is shared according to the difficulty and priority of the tasks. There is evidence that patients with Multiple Sclerosis (MS) have reduced performance during multitasking.

In this study, the investigators aim to investigate the effect of multitasking training on balance, mobility, upper extremity performance and cognitive functions in patients with MS.

Full description

Patients with MS between 0-1,5 score according to the Extended Disability Status Scale (EDSS) will be included in the study. The balance, mobility, upper extremity performance, the cognitive function will be evaluated twice.

The study was designed as a prospective, randomized controlled study. The patients will be randomly assigned to three groups, the "multi-task training (MT)" group, the "single task training (ST)" group, and "control" group. The training will be twice a week for 6 weeks.

Statistical analyses will be performed using the SPSS software version 15 (SPSS Inc. Chicago, IL, USA). The pre-training and post-training measurements of groups will be compared with the Wilcoxon Test. The significance level was set at p< 0.05

Enrollment: 39 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Participants who are ambulatory and volunteer to participate to the study, in a stable phase of the disease, without relapses in the last 3 month, with an EDSS between 0-1,5.

Exclusion criteria

• Participants who have orthopedic, vision, hearing, or perception problems

  • Patients who have any cardiovascular or pulmonary disease in which exercise is contraindicated

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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39 participants in 3 patient groups

Single task training

Active Comparator group

Description:

The exercise program consisting of 10 different motor tasks will be implemented in a single task training group.

Treatment:

Other: Single task training

Multi-task training

Experimental group

Description:

In the multitasking training group, a second motor task in the first two weeks, a cognitive task in the third and fourth week, both motor and cognitive tasks in the last two weeks will be added to these 10 different motor tasks.

Treatment:

Other: Multi-task training

Control group

No Intervention group

Description:

The control group will be taught relaxation exercises and will be asked to perform the exercises at home.