The Effect of N-acetylcysteine on Oxidative Stress Status and Iron Overload in Thalassemia Major

Beni-Suef University

Status and phase

Completed

Phase 1

Conditions

Thalassemia Major

Treatments

Drug: N-acetyl cysteine

Study type

Interventional

Funder types

Other

Identifiers

NCT04260516

FM-BSU REC

Details and patient eligibility

About

The effect of N-acetylcysteine as antioxidant and its effect on pretransfusion hemoglobin and iron overload in patients with thalassemia were compared to patients who didn't receive n-acetylcysteine after 3 months of study duration

Full description

N-acetylcysteine( NAC) is a widely used mucolytic drug and several studies had reported its efficacy as anti oxidant. Patients with thalassemia major are at great risk for oxidative stress due to excess of b-globin chains and iron overload. In this study the investigators compared the effect of NAC on oxidative status , pretransfusion hemoglobin levels and iron overload in thalassemia patients before and after treatment with NAC for 3 months and with that of patients who served as controls.

Enrollment

100 patients

Sex

All

Ages

3 to 14 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Thalassemia major children on regular blood transfusion and iron chelation therapy

Exclusion criteria

Renal or hepatic impairments
Complicated thalassemia major
Non adherence to therapy or follow up visits
Change in the iron chelation dose within 3 months before enrollment or during study period