The Effect of NB-UVB on Interleukin-36 Levels in Psoriasis

Cairo University (CU)

Status: Unknown

Conditions: Psoriasis

Treatments: Device: NB-UVB

Study type: Interventional

Funder types: Other

Identifiers

NCT03526705

Kapu1

Details and patient eligibility

About

Psoriasis is an immune-mediated skin disease that affects 1-2 % of the population. Several cytokines have been found to be involved in the complex pathogenesis of this disease. Il- 36 is one of the cytokines sharing in psoriasis pathogenesis, as its levels are elevated in psoriatic plaques. Cathepsin G is known to activate Il- 36 and promote inflammation in psoriasis.NB-UVB is one of the important treatment modalities for psoriasis.

The aim of this study is to detect the effect of NB-UVB on the lesional levels of IL-36 in psoriasis.

Full description

25 psoriasis patients will receive 26 sessions of phototherapy (NB-UVB). Patients will receive 3 sessions per week. Tissue levels of IL-36 and Cathepsin G will be assessed in skin lesions before starting treatment and after completing the 26 sessions.

Enrollment: 25 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with psoriasis vulgaris of both sexes
• Age between 18 and 60 years old.

Exclusion criteria

• Pregnant females
• Patients receiving systemic treatment or topical treatment for psoriasis within the past two months.
• Patients having other dermatological diseases.

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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25 participants in 1 patient group

nb-uvb

Experimental group

Description:

psoriasis patients will receive 26 sessions of nb-uvb phototherapy

Treatment:

Device: NB-UVB