The Effect of Negatively Fluid Balancing Speed for ICU Patients With Acute Respiratory Distress Syndrome

Qingdao University

Status: Unknown

Conditions: Fluid Loss

Treatments: Other: traditional speed; Other: faster speed

Study type: Interventional

Funder types: Other

Identifiers

NCT03552601

YB201806

Details and patient eligibility

About

Previous studies have shown that a positive fluid balance was an independent factor of worse prognosis in ICU patients with acute respiratory distress syndrome (ARDS), and negative fluid balance has been demonstrated to increase oxygenation index, reduce time under mechanical ventilation and ICU length of stay with no noticeable adverse effects. But there is no evidence that faster speed of negative fluid balance would be more beneficial for ARDS patients. So researchers designed the study to prove the effect of negatively fluid balancing speed for ICU patients with ARDS.

Enrollment: 70 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

·Patients with ARDS (Berlin 2012 criterion）

Exclusion criteria

• Pregnant women
• Unstable hemodynamics status
• < 18 years old

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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70 participants in 2 patient groups

traditional speed

Other group

Description:

The target amount of every day's net negative fluid balance for the first three days is 1000mL.

Treatment:

Other: traditional speed

faster speed

Other group

Description:

The target amount of every day's net negative fluid balance for the first three days is 1500mL.

Treatment:

Other: faster speed