The Effect of Non-surgical Periodontal Treatment in the Renal Function of Patients With Chronic Kidney Disease: RCT

National and Kapodistrian University of Athens

Status: Completed

Conditions: Chronic Kidney Disease; Periodontitis

Treatments: Procedure: Full Mouth Non-Surgical Periodontal Therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT01217281

143

Details and patient eligibility

About

Periodontal disease is a bacterially-induced inflammation. As such, it can become a point of entry of bacteria, toxins and cytokines into the systemic blood circulation, thus adversely affecting the function of kidneys. This is turn can aggravate the condition of patients with CKD.

The study hypothesis is that periodontal therapy can improve renal function in patients with CKD and lower the blood levels of markers for systemic inflammation.

Enrollment: 60 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Chronic Kidney Disease (Stage II, III, IV)
• At least 12 teeth present in the oral cavity
• Moderate to severe chronic periodontitis, which is defined as: at least 8 surfaces with periodontal pocket depth (PPD) ≥5mm and at least 4 surfaces with Clinical Attachment Loss (CAL) ≥4mm, distributed in at least two quadrants.

Exclusion criteria

• Patients that have had a renal transplant or undergoing dialysis
• Acute infections or use of antibiotics in the past 3 months.
• Auto-immune diseases, conditions that cause immunosuppression or use of immunosuppressant medication.
• Systemic conditions that require antibiotic prophylaxis for routine periodontal therapy.
• Non-surgical periodontal therapy in the past 6 months or surgical periodontal therapy in the past 12 months.
• Use of medication that can cause gingival hyperplasia such as cyclosporine or fenintoin.
• Myocardial infarction or cerebral vascular incident in the past 12 months or uncontrolled angina.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

Control

No Intervention group

Description:

Full mouth supra-gingival debridement using hand instruments and ultrasonic scalers, in one session. Patient motivation and oral hygiene instructions Review and prophylaxis at 1 month, 3 months and 6 months after initial treatment session. Full mouth periodontal therapy provided at the end of the 6month period (supra and sub- gingival full mouth scaling)

Test/ Non-surgical Periodontal Therapy

Active Comparator group

Description:

Full mouth periodontal therapy (sub and supra- gingival debridement) provided under local anaesthesia in two half-mouth sessions. Review and prophylaxis 1 month, 3 months and 6 months after the end of the initial therapy.

Treatment:

Procedure: Full Mouth Non-Surgical Periodontal Therapy