The Effect of Norepinephrine on the Development of Pressure Injury

Koç University

Status: Completed

Conditions: Pressure Injury

Study type: Observational

Funder types: Other

Identifiers

NCT06860308

NR24022025

Details and patient eligibility

About

Norepinephrine mainly increases mean arterial pressure among intensive care patients. It may be an essential risk factor in developing pressure injuries. However, there are still conflicting findings in the literature.

This study aimed to examine the effect of norepinephrine infusion on the development of pressure injuries among patients in adult intensive care.

This retrospective and correlational study was conducted between March 2021- May 2022. The electronic patient data were obtained from 289 adult patients (Case group n=149; control group n=149) treated with and without norepinephrine in the intensive care unit, respectively. The demographic and clinical characteristics were evaluated using descriptive statistical methods (number, percentage, mean, standard deviation). A logistic regression model was established to estimate the dependent variable (development of pressure injury) with the independent variables.

Enrollment: 289 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

The sample consisted of all patients

• over 18 years old
• who did not have pressure injuries upon admission to the intensive care unit. Patients who received norepinephrine and received norepinephrine infusion for at least 48 hours during their stay in ICU were included in the case group (n=149), and patients who did not receive an infusion were included in the control group (n=140).

Exclusion criteria

The sample excluded of all patients

• less than 18
• who have pressure injuries during admission
• who had norepinephrine infusion less than48 hours during their stay in the intensive care unit.

Trial design

289 participants in 2 patient groups

Case Group

Description:

Patients with norepinephrine infusion in the intensive care unit,

Control group

Description:

Patients without norepinephrine in the intensive care unit