The Effect of Nutritional Interventions on Exercise-induced Muscle Damage

Federal University of Health Science of Porto Alegre

Status: Completed

Conditions: Muscle Damage

Treatments: Dietary Supplement: Isolate whey protein; Other: Eccentric exercise; Dietary Supplement: Omega 3; Dietary Supplement: Omega 3 and Isolate whey protein

Study type: Interventional

Funder types: Other

Identifiers

NCT02839525

51384015.5.0000.5345

Details and patient eligibility

About

The study is a randomized, double-blinded, placebo-controlled trial that will include the participation of 69 women, aged 18-40 years. The aim of the study is to test nutritional strategies that help to minimize the effects of muscle damage induced by exercise.

The procedures will be performed at the Federal University of Health of Porto Alegre (UFCSPA).

Full description

The exercise-induced muscle damage is associated with eccentric activities affecting muscle structural unit through micro-injury that can promote a local inflammatory response, muscle damage and delayed onset muscle soreness. These events can cause an impact on athletic performance and lower adherence to the training programs. To optimize muscle recovery after the damage caused by exercise is essential to ensure adequate caloric intake , with required amounts of macronutrients and micronutrients. Recent studies have been showed that the protein intake before sleeping is a effective strategy to inhibit muscle protein degradation, stimulate muscle protein synthesis and facilitate adaptive response of skeletal muscle to physical exercise. Furthermore, evidences on the use of anti-inflammatory nutrients have suggested that diets rich in omega 3 can reduce inflammation through inhibition of pro-inflammatory mediators. Therefore, the intake of this nutrient combined with a protein meal before sleeps and the control of food intake can improve adherence to sports training. The study will consist of three groups where everyone will receive an individualized diet. A randomization procedure will determine the type of intervention. The distribution of the groups will be as follows: group 1 (control) - volunteers follow individualized diet and olive oil capsules and maltodextrin; group 2 - intervention with omega 3 more individualized diet ; group 3 - omega 3 and whey protein isolate intervention more individualized diet.

The order of procedures to be performed will be: (1) Nutritional and Anthropometric assessment; (2) Individual orientation of diet and distribution of supplements; (3) Baseline assessment (peak torque, muscle pain levels and vastus lateralis and rectus femoris echo intensity; (4) Muscle damage induction by eccentric exercise protocol; (5) Reviews after 24h, 48h, 72h, which will follow the routine and the methods applied at baseline.

Enrollment: 2 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 - 40 years aged
• BMI 18,5-25kg/m2
• physical exercise: < 150 minutes per week

Exclusion criteria

• pregnancy/ lactation
• vegetarian/vegan
• chronic disease
• pulmonary and neurologic disease
• muscle injury/knee muscle injury
• medication use: anti-inflammatory and anticoagulant
• fish oil and derivate allergy
• dietary supplements use in the last month: whey protein, casein, albumin, glutamin, meat and soy protein, creatine, branched chain amino acid, high calorie supplement, n-3 supplement and antioxidants

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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2 participants in 3 patient groups, including a placebo group

Omega 3

Placebo Comparator group

Description:

* 3000mg of olive oil * Eccentric exercise: 100 maximal eccentric contractions of knee extensors, divided into 10 sets of 10 repetitions at intervals of 60 seconds between the series

Treatment:

Other: Eccentric exercise

Dietary Supplement: Omega 3

Isolate whey protein

Placebo Comparator group

Description:

* 23g of maltodextrin * Eccentric exercise: 100 maximal eccentric contractions of knee extensors, divided into 10 sets of 10 repetitions at intervals of 60 seconds between the series

Treatment:

Other: Eccentric exercise

Dietary Supplement: Isolate whey protein

Omega 3 and Isolate whey protein

Placebo Comparator group

Description:

* 3000mg of olive oil and 23g of maltodextrin * Eccentric exercise: 100 maximal eccentric contractions of knee extensors, divided into 10 sets of 10 repetitions at intervals of 60 seconds between the series

Treatment:

Dietary Supplement: Omega 3 and Isolate whey protein

Other: Eccentric exercise