The Effect of Obesity on Endometrium in PCOS (OB-PCO)

Assiut University

Status: Completed

Conditions: Polycystic Ovary Syndrome; Body Weight

Treatments: Device: Doppler evaluation

Study type: Observational

Funder types: Other

Identifiers

NCT02694419

PCOS

Details and patient eligibility

About

The effect of Polycystic Ovary Syndrome (PCOS) with or without obesity has received a few attentions. There is a lack of evidence to whether the BMI affects the endometrial blood flow, which is necessary for implantation.

Enrollment: 100 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women with PCOS are diagnosed according to Rotterdam criteria, (Rotterdam and ASRM-Sponsored, 2004)by the presence of two out of the following three: oligomenorrhea (absence of menses for 35-182 days) or amenorrhea (absence of menses for >182 days), signs or symptoms of hyperandrogenism (acne, hirsutism), US showing polycystic ovaries.
• Fertile women had regular menstruation, with at least one previous spontaneous pregnancy.

Exclusion criteria

• Women known to have hepatic or renal dysfunction, Diabetes mellitus, hypertension, or cardiovascular disease.
• If they have used induction of ovulation drugs for the last three months.
• If they have used hormonal contraception in the last three months.

Trial design

100 participants in 4 patient groups

obese/PCO

Description:

Women with PCOS who are overweight\obese with BMI ≥ 25 kg/m2.

Treatment:

Device: Doppler evaluation

normal weight/PCO

Description:

Women with PCOS who are normal weight with BMI < 25 kg/m2.

Treatment:

Device: Doppler evaluation

Obese/fertile

Description:

Fertile regularly menstruating women with at least one previous spontaneous pregnancy who are overweight\obese with BMI ≥ 25 kg/m2.

Treatment:

Device: Doppler evaluation

normal weight/fertile

Description:

Fertile regularly menstruating women with at least one previous spontaneous pregnancy who are normal weight with BMI < 25 kg/m2.

Treatment:

Device: Doppler evaluation