The Effect of Obesity on Endometrium in PCOS (OB-PCO)

A

Assiut University

Status

Completed

Conditions

Polycystic Ovary Syndrome
Body Weight

Treatments

Device: Doppler evaluation

Study type

Observational

Funder types

Other

Identifiers

NCT02694419
PCOS

Details and patient eligibility

About

The effect of Polycystic Ovary Syndrome (PCOS) with or without obesity has received a few attentions. There is a lack of evidence to whether the BMI affects the endometrial blood flow, which is necessary for implantation.

Enrollment

100 patients

Sex

Female

Ages

18 to 40 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Women with PCOS are diagnosed according to Rotterdam criteria, (Rotterdam and ASRM-Sponsored, 2004)by the presence of two out of the following three: oligomenorrhea (absence of menses for 35-182 days) or amenorrhea (absence of menses for >182 days), signs or symptoms of hyperandrogenism (acne, hirsutism), US showing polycystic ovaries.
  • Fertile women had regular menstruation, with at least one previous spontaneous pregnancy.

Exclusion criteria

  • Women known to have hepatic or renal dysfunction, Diabetes mellitus, hypertension, or cardiovascular disease.
  • If they have used induction of ovulation drugs for the last three months.
  • If they have used hormonal contraception in the last three months.

Trial design

100 participants in 4 patient groups

obese/PCO
Description:
Women with PCOS who are overweight\obese with BMI ≥ 25 kg/m2.
Treatment:
Device: Doppler evaluation
normal weight/PCO
Description:
Women with PCOS who are normal weight with BMI < 25 kg/m2.
Treatment:
Device: Doppler evaluation
Obese/fertile
Description:
Fertile regularly menstruating women with at least one previous spontaneous pregnancy who are overweight\obese with BMI ≥ 25 kg/m2.
Treatment:
Device: Doppler evaluation
normal weight/fertile
Description:
Fertile regularly menstruating women with at least one previous spontaneous pregnancy who are normal weight with BMI < 25 kg/m2.
Treatment:
Device: Doppler evaluation

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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