The Effect of Obesity on Growth Hormone Response to Anaerobic Exercise

Clalit Health Services

Status: Unknown

Conditions: Obesity

Study type: Observational

Funder types: Other

Identifiers

NCT01070589

MMC01922009CTIL

Details and patient eligibility

About

The aim of the present study is to asses the effect of obesity on anaerobic exercise's growth hormone (GH) response.

Full description

Exercise is a potent physiological stimulator of growth hormone (GH) release. GH is an important factor in the distribution of fat and lean tissue in the body. Previous studies suggested that the GH response to aerobic exercise may be attenuated by obesity. The effect of obesity on GH response to anaerobic effort is unclear. The aim of the present study is to asses the effect of obesity on anaerobic exercise's GH response. We will recruit 12 obese (BMI > 30) healthy adults and 12 age and gender matched normal weight (BMI < 25) controls. All the participants will conduct a "wingate" anaerobic test (30 seconds of intense effort against resistance calculated by the individual's body weight). Blood sample for GH level will be collected at 5 different time (0, 20, 30, 40 and 60 minutes after the test). We will compare the GH response in the two groups.

Enrollment: 24 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy female
• Age 18-40

Exclusion criteria

• Male
• Age <18, >40
• Heart, Liver, Kidney or Hypophyseal disease
• Medications that may alter GH secretion (eg Steroids, Eltroxin)

Trial design

24 participants in 2 patient groups

Group 1: Obese

Description:

BMI\>30

Group 2: control

Description:

Group 2:Normal weight (BMI \<25). age and gender matched.