The Effect of Ocular Rinse Volume on Surface Irritation After Intravitreal Injections

University of Oklahoma (OU)

Status: Completed

Conditions: Ocular Rinse; Intravitreal Injection; Age-Related Macular Degeneration; Diabetic Macular Edema; Cystoid Macular Edema

Treatments: Other: SPEEDII questionnaire; Other: OSDI questionnaire

Study type: Interventional

Funder types: Other

Identifiers

NCT05615805

IRB #9810

Details and patient eligibility

About

This is the first randomized controlled trial looking into post-injection rinse volume of standard ophthalmic eyewash and its affect on patient comfort up to 72 hours after injections.

Full description

Purpose To evaluate whether the volume of wash out rinse after povidone iodine (PI) application for intravitreal injections (IVI) affects patients' ocular surface irritation.

Methods This was a prospective, single-masked, randomized-controlled trial consisting of 142 subjects . A total of 51, 45, and 46 patients received 3-mL, 10-mL, and 15-mL of ocular rinse respectively. Reductions in the Ocular Surface Disease Index (OSDI) and the Standardized Patient Evaluation of Eye Dryness II (SPEED II) surveys, conducted before and at 24-72 hours post-injection, were analyzed.

Enrollment: 142 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

choroidal neovascular membrane or cystoid macular edema requiring intravitreal injections for treatment.

Exclusion criteria

active ocular infection, eyelid trauma, graft versus host disease, thyroid eye disease, pregnancy.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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142 participants in 3 patient groups

3-mL washout with saline based ocular rinse post injection

Experimental group

Treatment:

Other: SPEEDII questionnaire

Other: OSDI questionnaire

10-mL washout with saline based ocular rinse post injection

Experimental group

Treatment:

Other: SPEEDII questionnaire

Other: OSDI questionnaire

15-mL washout with saline based ocular rinse post injection

Experimental group

Treatment:

Other: SPEEDII questionnaire

Other: OSDI questionnaire