The Effect of Omega-3 Supplementation on Muscle Functioning, Inflammation and Muscle Signaling

Catholic University (KU) of Leuven

Status: Completed

Conditions: Aging

Treatments: Dietary Supplement: Placebo - appearance-matched oil supplementation; Other: Resistance exercise; Dietary Supplement: Omega-3 polyunsaturated fatty acid supplementation

Study type: Interventional

Funder types: Other

Identifiers

NCT03986307

S61809

Details and patient eligibility

About

Elderly are supplemented with either Omega-3 (3 x 1.1g per day) or placebo (corn oil) during 14 weeks. The last 12 weeks, supplementation is combined with resistance exercise training (3x per week) focusing on upper leg strength. In the present project, the investigators study whether differences in muscle strength and/or muscle mass between conditions can be explained by omega-3-induced effects on systemic or muscle inflammatory signaling, or differences in muscle molecular signaling.

Full description

Elderly are supplemented with either Omega-3 (3 x 1.1g per day) or placebo (corn oil) during 14 weeks. The last 12 weeks, supplementation is combined with resistance exercise training (3x per week) focusing on upper leg strength. In the present project, the investigators study whether differences in muscle strength and/or muscle mass between conditions can be explained by omega-3-induced effects on systemic or muscle inflammatory signaling, or differences in muscle molecular signaling.

Enrollment: 23 patients

Sex: All

Ages: 65 to 100 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• aged >= 65 years

Exclusion criteria

• BMI < 20; BMI > 35
• regular NSAID intake in the last 3 months
• omega-3 supplementation in the last year
• regular resistance exercise in the last year
• cancer, liver and renal disease, unstable cardiovascular disease, musculoskeletal disease
• cognitive limitations that might interfere with the (adherence to) the intervention or with the testing of outcome parameters
• unstable body weight
• smoking

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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23 participants in 2 patient groups, including a placebo group

Omega-3

Experimental group

Description:

Elderly supplemented with omega-3.

Treatment:

Other: Resistance exercise

Dietary Supplement: Omega-3 polyunsaturated fatty acid supplementation

Placebo

Placebo Comparator group

Description:

Elderly supplemented with corn oil.

Treatment:

Other: Resistance exercise

Dietary Supplement: Placebo - appearance-matched oil supplementation