the Effect of Opioid-free General Anesthesia

The Catholic University of Korea

Status: Completed

Conditions: Gynecologic Disease

Treatments: Drug: Remifentanil Hydrochloride; Drug: Lidocaine Hydrochloride; Drug: Dexmedetomidine Hydrochloride

Study type: Interventional

Funder types: Other

Identifiers

NCT04409964

OFGA

Details and patient eligibility

About

This study is performed to investigate the effect of opioid-free general anesthesia on the recovery quality after gynecological laparoscopy.

Full description

The quality of recovery after the surgery is assessed using the QoR 40. In addition, the various kinds of cytokine are assessed for the ancillary study.

Enrollment: 78 patients

Sex: Female

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient scheduled for gynecological laparoscopic surgery

Exclusion criteria

1. refusal to participate in this study
2. emergent surgery
3. chronic pain requiring for pain killer
4. psychiatric disease
5. preoperative bradycardia or hypotension
6. allergy or history of the adverse effect to study drug
7. pregnancy or lactation

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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78 participants in 2 patient groups

opioid-free anesthesia

Experimental group

Description:

The study group receives the dexmedetomidine and lidocaine infusion with general anesthesia for gynecological laparoscopy.

Treatment:

Drug: Dexmedetomidine Hydrochloride

Drug: Lidocaine Hydrochloride

opioid anesthesia

Active Comparator group

Description:

The control group receives the remifentanil infusion with general anesthesia for gynecological laparoscopy.

Treatment:

Drug: Remifentanil Hydrochloride