The Effect of Oral and Intravenous Ramosetron During Laparoscopic Cholecystectomy

Seoul National University

Status: Unknown

Conditions: Vomiting; Nausea; Laparoscopic Cholecystectomy

Treatments: Drug: intravenous ramosetron; Drug: oral ramosetron; Drug: oral and IV ramosetron

Study type: Interventional

Funder types: Other

Identifiers

NCT01041183

nasea-LC

Details and patient eligibility

About

Patients undergoing general anesthesia for laparoscopic cholecystectomy have a high risk of postoperative nausea and vomiting (PONV). The investigators investigated the effect of oral and IV ramosetron on PONV prophylaxis after laparoscopic cholecystectomy.

Enrollment: 120 estimated patients

Sex: All

Ages: 25 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I-II patients, 25-65 years, electivelaparoscopic cholecystectomy under general anesthesia

Exclusion criteria

• GI disease, pregnant or menstruating, history of motion sickness and/or postoperative emesis, antiemetics within 24 h before surgery

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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120 participants in 3 patient groups

group I

Active Comparator group

Description:

0.3 mg IV ramosetron

Treatment:

Drug: intravenous ramosetron

group II

Active Comparator group

Description:

0.1 mg oral ramosetron

Treatment:

Drug: oral ramosetron

group III

Active Comparator group

Description:

0.1 mg oral ramosetron plus 0.3 mg IV ramosetron

Treatment:

Drug: oral and IV ramosetron