The Effect of Oral Intake of Animal and Plant Proteins on the Metabolism in Healthy Women (PAN-Promet)

Örebro University, Sweden

Status: Active, not recruiting

Conditions: Healthy

Treatments: Dietary Supplement: Isolated Pea Protein; Dietary Supplement: Isolated Whey Protein; Dietary Supplement: Placebo; Dietary Supplement: Isolated Faba Bean Protein

Study type: Interventional

Funder types: Other

Identifiers

NCT06045611

Dnr 2023-03852-01

Details and patient eligibility

About

The goal of this interventional study is to learn about the effects of different proteins (from animals or plants) on the metabolism in healthy, normal weight women between 18-45 year who are not on hormonal birth-control.

The main questions the study aims to answer are:

1. How do different proteins affect biological markers of the metabolism and which protein has the strongest effect?
2. How are the different proteins digested and taken up from our body?

Participants will drink four different shakes on four different study days in a random order. Three of them contain each a different protein and one does not contain protein. Right before drinking the shake and on 11 timepoints after drinking the shake blood samples will be drawn.

Enrollment: 28 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Females
• Age: 18-45 years
• Body mass index: 18.5 < 25 kg/m2
• Signed informed consent

Exclusion criteria

• Use of hormonal contraceptives
• Pregnancy or breastfeeding
• Diabetes mellitus or any other metabolic disease that might affect the results of this study
• Gastric surgery that affects digestion and uptake of protein
• Any clinically significant present or past disease/condition and medication which in the investigator's opinion could interfere with the results of the trial

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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28 participants in 4 patient groups

Isolated Pea Protein/Isolated Whey Protein/Isolated Faba Bean Protein/Placebo

Experimental group

Description:

* Study day 1: 0.6g isolated pea protein/kg/body weight + 400 ml water * Study day 2: 0.6g isolated whey protein/kg/body weight + 400 ml water * Study day 3: 0.6g isolated faba bean protein/kg/body weight + 400 ml water * Study day 4: 400 ml water The fat and energy content of the drinks will be adapted using a plant based oil

Treatment:

Dietary Supplement: Isolated Faba Bean Protein

Dietary Supplement: Placebo

Dietary Supplement: Isolated Whey Protein

Dietary Supplement: Isolated Pea Protein

Isolated Whey Protein/Placebo/Isolated Pea Protein/Isolated Faba Bean Protein

Experimental group

Description:

* Study day 1: 0.6g isolated whey protein/kg/body weight + 400 ml water * Study day 2: 400 ml water * Study day 3: 0.6g isolated pea protein/kg/body weight + 400 ml water * Study day 4: 0.6g isolated faba bean protein/kg/body weight + 400 ml water The fat and energy content of the drinks will be adapted using a plant based oil

Treatment:

Dietary Supplement: Isolated Faba Bean Protein

Dietary Supplement: Placebo

Dietary Supplement: Isolated Whey Protein

Dietary Supplement: Isolated Pea Protein

Isolated Faba Bean Protein/Isolated Pea Protein/Placebo/Isolated Whey Protein

Experimental group

Description:

* Study day 1: 0.6g isolated faba bean protein/kg/body weight + 400 ml water * Study day 2: 0.6g isolated pea protein/kg/body weight + 400 ml water * Study day 3: 400 ml water * Study day 4: 0.6g isolated whey protein/kg/body weight + 400 ml water The fat and energy content of the drinks will be adapted using a plant based oil

Treatment:

Dietary Supplement: Isolated Faba Bean Protein

Dietary Supplement: Placebo

Dietary Supplement: Isolated Whey Protein

Dietary Supplement: Isolated Pea Protein

Placebo/Isolated Faba Bean Protein/Isolated Whey Protein/Isolated Pea Protein

Experimental group

Description:

* Study day 1: 400 ml water * Study day 2: 0.6g isolated faba bean protein/kg/body weight + 400 ml water * Study day 3: 0.6g isolated whey protein/kg/body weight + 400 ml water * Study day 4: 0.6g isolated pea protein/kg/body weight + 400 ml water The fat and energy content of the drinks will be adapted using a plant based oil

Treatment:

Dietary Supplement: Isolated Faba Bean Protein

Dietary Supplement: Placebo

Dietary Supplement: Isolated Whey Protein

Dietary Supplement: Isolated Pea Protein