the Effect of Oral Vasopressors for Liberation From IV Vasopressors in Spinal Shock

Ahmed talaat ahmed aly

Status and phase: Unknown; Phase 2

Conditions: Spinal Shock

Treatments: Drug: Minirin oral tablet; Drug: Nor-Adrenaline; Drug: Midodrine Oral Tablet

Study type: Interventional

Funder types: Other

Identifiers

NCT04586790

oral vasopressors

Details and patient eligibility

About

the study is developed to evaluate the effect of use of oral vasopressors (midodrine versus minirin) on weaning ICU patients from IV vasopressors (noradrenaline) and compare between them for efficacy in shortage the duration of IV vasopressor and has low complications and side effects.

Enrollment: 90 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age of 18 - 60 years.
• Patients of both genders.
• Patients diagnosed by spinal shock and they are in the recovery stage .

Exclusion criteria

• Patient refusal.
• Anuric or oliguric patients or patients with chronic kidney disease.
• Patients with allergy to medication included in the study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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90 participants in 3 patient groups

midodrine group

Experimental group

Description:

midodrine group will receive midodrine 10 mg PO q8hr with gradual weaning of IV noradrenaline after receiving 4 doses of oral midodrine

Treatment:

Drug: Midodrine Oral Tablet

minirin group

Experimental group

Description:

the patients will receive minirin 60 µg PO q8hr with gradual weaning of IV noradrenaline after receiving 4 doses of oral minirin

Treatment:

Drug: Minirin oral tablet

control group

Experimental group

Description:

the patients will receive IV nor-adrenaline and are gradually weaning from it according to routine hospital care without adding oral midodrine or oral minirin .

Treatment:

Drug: Nor-Adrenaline