The Effect of Oxytocin on the Acquisition and Consolidation of Trauma-Associated Memories

Charité University Medicine Berlin

Status: Completed

Conditions: Intrusive Memories

Treatments: Drug: Placebos; Drug: Oxytocin nasal spray

Study type: Interventional

Funder types: Other

Identifiers

NCT03031405

Charite2017-Oxytocin-Study

Details and patient eligibility

About

The purpose of the study is to examine whether oxytocin and oxytocin receptor gene polymorphism affect the development of intrusive memories, a cardinal symptom of PTSD.

Enrollment: 220 patients

Sex: Female

Ages: 18 to 44 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy female volunteers
• German on a native level

Exclusion criteria

• former or present disorder according to the Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5)
• any physical illnesses
• any medication intake (except oral contraceptive)
• history of traumatic experience, e.g. history of sexual abuse or rape
• pregnancy or lactation period
• follicular phase of menstrual cycle for all women not using oral contraceptives

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Triple Blind

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220 participants in 2 patient groups, including a placebo group

Oxytocin and trauma film paradigm

Experimental group

Treatment:

Drug: Oxytocin nasal spray

Placebo and trauma film paradigm

Placebo Comparator group

Treatment:

Drug: Placebos