The Effect of Oxytocin on the Consolidation of Trauma-Associated Memories

Charité University Medicine Berlin

Status: Completed

Conditions: PTSD; Intrusive Memories

Treatments: Drug: Oxytocin; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT03875391

Charite2019-Oxytocin-Study

Details and patient eligibility

About

The purpose of the study is to examine whether oxytocin and certain polygenic risk scores affect the development of intrusive memories, a cardinal symptom of PTSD.

Enrollment: 217 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy female volunteers
• German on a native level

Exclusion criteria

• former or present disorder according to the Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5)
• any physical illnesses
• any medication intake (except oral contraceptive)
• history of traumatic experience, e.g. history of sexual abuse or rape
• pregnancy or lactation period
• follicular phase of menstrual cycle for all women not using oral contraceptives

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Triple Blind

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217 participants in 2 patient groups, including a placebo group

Oxytocin and trauma film paradigm

Experimental group

Description:

Intervention: Drug: Oxytocin nasal spray

Treatment:

Drug: Oxytocin

Placebo and trauma film paradigm

Placebo Comparator group

Description:

Intervention: Drug: Placebos

Treatment:

Drug: Placebo