The Effect of Parecoxib Sodium Intravenous Patient-controlled Analgesia in Laparotomic Liver Resection

Harbin Medical University

Status: Unknown

Conditions: Pain, Postoperative

Treatments: Procedure: intravenous infusion pump of patient-controlled analgesia; Drug: fentanyl citrate+ ondansetron hydrochloride + normal saline; Procedure: conventional intravenous infusion pump; Drug: parecoxib; Drug: celecoxib

Study type: Interventional

Funder types: Other

Identifiers

NCT02408146

Lianxin-001

Details and patient eligibility

About

The investigators hypothesized that using new intravenous infusion pump of patient-controlled analgesia (parecoxib sodium 1 mg/mL + normal saline) would significantly improve postoperative pain control compare to conventional intravenous infusion pump of patient-controlled analgesia (fentanyl citrate 20 mg/mL/kg + ondansetron hydrochloride 16 mg/8 mL + normal saline). This prospective randomized controlled trial was designed to evaluate the benefit of new intravenous infusion pump of patient-controlled analgesia (parecoxib sodium 1 mg/mL + normal saline) for postoperative analgesia after laparotomic liver resection.

Enrollment: 80 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients need laparotomic liver resection.

Exclusion criteria

Patients with contraindications to spinal anesthesia or intrathecal morphine, difficulty understanding passive cutaneous anaphylaxis, a history of drug dependence or chronic pain, body mass index greater than 35 kg/m2, or history of sleep apnea were excluded from this study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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80 participants in 3 patient groups

conventional intravenous infusion pump

Experimental group

Description:

The first group receives conventional intravenous infusion pump of patient-controlled analgesia.

Treatment:

Drug: fentanyl citrate+ ondansetron hydrochloride + normal saline

Procedure: conventional intravenous infusion pump

parecoxib

Experimental group

Description:

The second group has oral celecoxib before surgery, then receives parecoxib sodium intravenously guttae after surgery.

Treatment:

Drug: parecoxib

Drug: celecoxib

new intravenous infusion pump

Experimental group

Description:

The third group uses new intravenous infusion pump of patient-controlled analgesia after surgery.

Treatment:

Drug: parecoxib

Drug: celecoxib

Procedure: intravenous infusion pump of patient-controlled analgesia