The Effect of Parenteral Nutrition Supplement on Esophagectomy Patients

Fudan University

Status: Completed

Conditions: Esophagus Cancer

Treatments: Other: Enteral Nutrition alone for patients after esophagectomy; Other: Parenteral supplement with enteral nutrition for patients after esophagectomy

Study type: Interventional

Funder types: Other

Identifiers

NCT01669356

Energy Supply Trial (Other Identifier)

PNsupplESO

Details and patient eligibility

About

Malnutrition is common in esophagus cancer patients, especially after surgery therapy. Whether parenteral supplement with enteral nutrtion is benificial for patients after esophagectomy is controversial, when compared with enteral nutrition alone. In this study, the investigators are to examine the effect of enteral nutrition supplemented with parenteral nutrtion on nutrition status after esophagectomy.

Enrollment: 95 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of esophagus cancer
• Undergo esophagectomy
• Nasoenteral tube is placed or surgical jejunostomy is performed

Exclusion criteria

• Contraindication for enteral nutrition or parenteral nutrition
• Malnutrition before surgery ( BMI > 30 or < 18.5)
• Hepatic dysfunction preoperatively
• Renal dysfunction preoperatively
• Infection before surgery
• Usage of corticosteroid before surgery

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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95 participants in 2 patient groups

PN supplement

Experimental group

Description:

Parenteral supplement with enteral nutrition for patients after esophagectomy

Treatment:

Other: Parenteral supplement with enteral nutrition for patients after esophagectomy

EN alone

Active Comparator group

Description:

Enteral nutrition alone for patients after esophagectomy

Treatment:

Other: Enteral Nutrition alone for patients after esophagectomy