The Effect of Pasteurized; Pasteurized and Homogenized and UHT Treated Homogenized Cow's Milk on Gastrointestinal Symptoms in Sensitive Adults

University of Turku

Status: Completed

Conditions: Unidentified Gastrointestinal Discomfort Following Dairy Consumption

Treatments: Other: Dietary intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT03010904

MILK2

Details and patient eligibility

About

This study aims to investigate differences in digestion rates and gastrointestinal problems caused by pasteurized; pasturized and homogenized as well as UHT-treated homogenized cow's milks in healthy adults by diary of symptoms, blood glucose and triacylglycerol levels and plasma cytokine levels.

Enrollment: 14 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Homogenized and pasteurized milk causes gastrointestinal problems (self-reported) unhomogenized and unpasteurized milk does not cause gastrointestinal problems (self-reported)
• age 18-65
• BMI 18,5 - 30
• hemoglobin under normal range
• fasting plasma alanine aminotransferase ALAT < 60 U/l (normal liver function)
• fasting plasma thyroid-stimulating hormone (TSH) 0.4 - 4.5 mU/l (normal thyroid function)
• fasting plasma creatinine < 118 umol/l (normal kidney function)

Exclusion criteria

• pace maker
• Crohn's disease or other disease of the intestinal tract
• intestinal operation within the last 3 months
• difficult dysphagia
• smoking
• constipation
• lactose intolerance
• coeliac disease

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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14 participants in 3 patient groups

pasteurized milk

Experimental group

Description:

milk that has undergone pasteurization treatment

Treatment:

Other: Dietary intervention

homogenized pasteurized milk

Experimental group

Description:

Milk that has undergone homogenization and pasteurization treatment

Treatment:

Other: Dietary intervention

UHT milk

Experimental group

Description:

Milk that has undergone homogenization and ultra high temperature treatment

Treatment:

Other: Dietary intervention