The Effect of PCA on PONV After Microvascular Decompression

Seoul National University

Status: Enrolling

Conditions: Postoperative Nausea and Vomiting

Treatments: Drug: Opioid; Drug: NSAID

Study type: Interventional

Funder types: Other

Identifiers

NCT05189704

MVD-PCA

Details and patient eligibility

About

This study is a randomized, controlled, double-blinded, and parallel design study. A total 94 patients will be randomized to receive ketorolac or fentanyl based patient-controlled analgesia after microvascular decompression surgery.

Enrollment: 94 estimated patients

Sex: All

Ages: 19 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who undergo elective microvascular decompression surgery
• American Society of Anesthesiologists grade 1 or 2
• 19 - 65 years old

Exclusion criteria

• Refuse to participate to the study
• Refuse to use Patient-controlled analgesia
• Body Mass Index < 18.5 kg/m2 or > 35 kg/m2
• history of craniotomy or chemotheraphy
• Patients who used preoperative antiemetics within 24h before surgery
• Severe renal or hepatic dysfunction
• Pregnant

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

94 participants in 2 patient groups

NSAID group

Experimental group

Description:

NSAID based patient-controlled analgesia will connected to intravenous line for pain control.

Treatment:

Drug: NSAID

Opioid group

Active Comparator group

Description:

Opioid based patient-controlled analgesia will connected to intravenous line for pain control.

Treatment:

Drug: Opioid