The Effect of Periodontal Treatment on Psoriasis

Ozge Gokturk

Status: Completed

Conditions: Periodontal Diseases

Treatments: Other: Non-surgical periodontal treatment; Other: Psoriatic measurements; Other: saliva samples

Study type: Interventional

Funder types: Other

Identifiers

NCT03939936

17-KAEK-44

Details and patient eligibility

About

There is a relationship between psoriasis and periodontal disease. This relationship may be double-sided.

Full description

The aim of this randomized controlled clinical study was to determine the effect of non-surgical mechanical periodontal treatment on psoriasis. The study population consisted of 92 periodontitis patients with psoriasis who had untreated periodontal disease. Two randomized groups were formed from these patients. Immediate periodontal treatment (test group, n = 46) and delayed periodontal treatment (control group, n = 46). Clinical periodontal measures, saliva interleukin 2, interleukin 6 and secretory immunoglobulin A levels and PASI scores were performed at baseline and 8th week in control and test group.

Enrollment: 92 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• the presence at least 20 remaining teeth,
• the presence of Stage I or Stage II Periodontitis,
• the presence of diagnosed psoriasis.

Exclusion criteria

• patients who had the immune-inflammatory disease and require antibiotic prophylaxis,
• patients who received periodontal treatment prior to 6 months,
• women who were breastfeeding or pregnant,
• patients using medicines such as antibiotics, anti-inflammatory drugs, immune-suppressants.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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92 participants in 2 patient groups, including a placebo group

Test Group

Active Comparator group

Description:

Psoriatic measurements and saliva samples were taken from periodontal disease patients before treatment and after 8 weeks. Intervention: Non-surgical periodontal treatment was performed and the Psoriasis Area and Severity Index (PASI) was filled, saliva samples were taken.

Treatment:

Other: Psoriatic measurements

Other: Non-surgical periodontal treatment

Other: saliva samples

Control Group

Placebo Comparator group

Description:

Psoriatic measurements and saliva samples were taken from periodontal disease patients at the baseline and after 8 weeks without the periodontal treatment. Intervention: Psoriasis Area and Severity Index (PASI) was filled, saliva samples were taken.

Treatment:

Other: Psoriatic measurements

Other: saliva samples