The Effect of Perioperative Hyperglycemia on Anastomotic Leaks After Total Gastrectomy

Taner Abdullah

Status: Completed

Conditions: Hyperglycaemia; Total Gastrectomy; Anastomotic Leaks

Study type: Observational

Funder types: Other

Identifiers

NCT07140991

2025-183

Details and patient eligibility

About

Esophagojejunostomy anastomosis is used in total gastrectomy surgeries. Anastomotic leakage is a serious complication seen after these surgeries and is associated with increased morbidity and mortality. Patients with older age and comorbidities have a higher risk of death following anastomotic leakage.

Perioperative hyperglycemia is frequently observed in patients undergoing major abdominal surgery as a stress response to surgical trauma, leading to surgical complications through mechanisms such as glycogenolysis, lipolysis, gluconeogenesis, decreased insulin sensitivity, and increased insulin resistance. Hyperglycemia is known to increase the risk of postoperative infection, prolong hospital stay, and increase mortality. Additionally, recent studies have shown that it also increases the risk of anastomotic leakage.

Full description

Although diabetes mellitus is a known risk factor for anastomotic leaks, there are few studies on the relationship between perioperative hyperglycemia and anastomotic leaks. The primary objective of our study was to demonstrate the relationship between hyperglycemia detected during anastomosis formation in the perioperative period and postoperative anastomotic leaks.

Enrollment: 102 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• elective total gastrectomy
• anastomotic leak after surgery
• age 18-75

Exclusion criteria

• emergency procedure
• <18 years
• >75 years
• ASA score > 3

Trial design

102 participants in 1 patient group

hyperglycemia

Description:

Patients identified as hyperglycemic in the perioperative period