The Effect of Perioperative Lidocaine Infusion on Neutrophil Extracellular Trapping

The Catholic University of Korea

Status: Active, not recruiting

Conditions: Urologic Cancer

Treatments: Drug: lidocaine group; Drug: control group

Study type: Interventional

Funder types: Other

Identifiers

NCT04840511

NETosis-prostate Ca

Details and patient eligibility

About

This study will be done to investigate perioperative lidocaine infusion on neutrophil extracellular trapping in the patients undergoing the robot-assisted prostatectomy.

Full description

Neutrophil extracellular trapping by analyzing the meyloperoxidase, neutrophil elastase, citrullinated histone3

Enrollment: 60 estimated patients

Sex: Male

Ages: 20 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients scheduled robot-assisted prostatectomy

Exclusion criteria

• lidocaine allergy Hx
• hemodynamic unstable patients
• weight < 40kg
• arrhythmia or bradycardia

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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60 participants in 2 patient groups, including a placebo group

lidocaine group

Experimental group

Description:

The study group receives perioperative lidocaine infusion with general anesthesia for robot-assisted prostatectomy

Treatment:

Drug: lidocaine group

control group

Placebo Comparator group

Description:

The control group receives normal saline infusion with with general anesthesia for robot-assisted prostatectomy

Treatment:

Drug: control group