The Effect of Perioperative Lidocaine Infusion on Neutrophil Extracellular Trapping

The Catholic University of Korea

Status: Withdrawn

Conditions: Gastric Cancer

Treatments: Drug: normal saline; Drug: Lidocaine

Study type: Interventional

Funder types: Other

Identifiers

NCT04868747

NET-lidocaine-stomach cancer

Details and patient eligibility

About

To investigate the effect of perioperative lidocaine infusion on the neutrophil extracellular trapping after minimally invasive surgery for stomach cancer

Full description

To investigate the effect of perioperative lidocaine infusion on the neutrophil extracellular trapping, especially citrullinated histone3, neutrophil elastase, myeloperoxidase

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosis of stomach cancer
• ASA class I-III
• no metastatic disease

Exclusion criteria

• hepatic, renal disease
• chronic inflammatory disease, eg. rheumatoid arthritis
• steroid or anti-inflammatory drug medication
• allergies to study drugs
• neuropsychiatric disease
• refusal of participation
• breast feeding or pregnancy
• weight < 40 kg

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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0 participants in 2 patient groups, including a placebo group

study group

Experimental group

Description:

The study group receives the intravenous 1% lidocaine 1.5 mg/kg bolus followed by 1.5 mg/kg/h during surgery and 1.0 mg/kg/h until 24 hours after surgery (Max.\<120 mg/h).

Treatment:

Drug: Lidocaine

control group

Placebo Comparator group

Description:

The control group receives intravenous normal saline 0.15 ml/kg bolus followed by 0.15 ml/kg/h during surgery and 0.1 mg/kg/h until 24 hours after surgery.

Treatment:

Drug: normal saline