The Effect of Periradial Injection of Papaverine Versus Nitroglycerine on Radial Artery Diameter

Kasr El Aini Hospital

Status and phase: Completed; Early Phase 1

Conditions: Radial Artery Injury Prevetion

Treatments: Drug: nitroglycerine; Drug: xlyocaine; Drug: papaverine

Study type: Interventional

Funder types: Other

Identifiers

NCT04030663

FWA00015574

Details and patient eligibility

About

Compare the effect of periradial injection of papaverine versus nitroglycerine on radial artery diamter before cannulation of it in cardiac surgery.

Full description

we want in this study to facilitate radial artery canulation and decrease the number of attemps of puncture which may lead to disappearance of the pulse.

The aim of this study is to compare the effect of adding papaverine to local anesthetic xylocaine versus adding nitroglycerine to it on the diameter and palpability of radial artery and if perioperative spasm will decrease significantly with one of these methods.

Enrollment: 90 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who will be included in the study are those scheduled for elective cardiac surgery who are hemodynamically stable.

Exclusion criteria

• Any patient with negative modified Allen test, atrioventricular block, glaucoma, altered liver function, unstable hemodynamics, emergency surgeries, and peripheral vascular disease.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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90 participants in 3 patient groups, including a placebo group

papaverine

Active Comparator group

Treatment:

Drug: papaverine

nitroglycerine

Active Comparator group

Treatment:

Drug: nitroglycerine

xlyocaine

Placebo Comparator group

Treatment:

Drug: xlyocaine