The Effect of PHGG-rich Enteral Nutrition to on the Infection in Liver Transplant Recipients: A Prospective, Double-blind, Randomized Controlled Study

Sun Yat-sen University

Status and phase: Not yet enrolling; Phase 4

Conditions: Infections

Treatments: Drug: PHGG-rich enteral nutrtiion

Study type: Interventional

Funder types: Other

Identifiers

NCT05543226

2022-KY-029

Details and patient eligibility

About

To known the effect of PHGG-rich enteral nutrition to on the infection in liver transplant recipients

Enrollment: 136 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. liver transplant recipients
2. age from 18 to 80 years old
3. APACHE II score >12
4. There is an indication for enteral nutrition and it is expected to require oral or tube feeding for more than 7 days
5. there is no intra-abdominal infection or bloodstream infection

Exclusion criteria

1. Severe cardiac, kidney and lung dysfunction
2. bowel obstruction, intestinal perforation, intestinal leakage before operation
3. Roux and Y anastomosis during liver transplant

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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136 participants in 2 patient groups, including a placebo group

PHGG

Experimental group

Treatment:

Drug: PHGG-rich enteral nutrtiion

without PHGG

Placebo Comparator group

Treatment:

Drug: PHGG-rich enteral nutrtiion