The Effect of Physical Activity on the Brain

University Hospital Muenster

Status and phase: Unknown; Phase 3

Conditions: Unchanged Condition; Aerobic Exercise; Anaerobic Exercise

Treatments: Behavioral: exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT01475396

Exercise_Neuromod

Details and patient eligibility

About

Physical activity is thought to increase overall body functions and to decrease cardiovascular and stroke risk factors. Now the question arose, wether enhanced exercise could also exert positive influence on cognition in the aging brain. Therefore, 50 to 80 years old healthy subjects take part in a prospective study with regular sports activity during 6 months. Cognitive functions are detected with sensitive neuropsychological outcome measures, further investigations include MRT of the head, lactat- and other physical measures as well as detailed serum profiles. As a hypothesis, enhanced physical activity is suggested to predict better cognitive performance.

Enrollment: 120 estimated patients

Sex: All

Ages: 50 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 50-80 years old
• healthy
• lesser activity

Exclusion criteria

• regular physical activity
• diabetes
• stroke
• heavy smoking, drinking,
• BMI < 20
• MMSE < 25

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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120 participants in 3 patient groups

Aerobic Exercise

Experimental group

Treatment:

Behavioral: exercise

Anaerobic Exercise

Experimental group

Treatment:

Behavioral: exercise

Unchanged condition

No Intervention group