The Effect of Pnemoperitoneum on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Surgery According to Anesthesia Agents: Propofol Based Total Intravenous Anesthesia vs Desflurane Anesthesia

Yonsei University

Status: Withdrawn

Conditions: Optic Nerve Sheath

Treatments: Drug: Propofol; Drug: Desflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT02003768

4-2013-0626

Details and patient eligibility

About

The pneumoperitoneum during laparoscopic surgery have the potential to cause an increase of intracranial pressure (ICP). Previous studies have proposed that ultrasonographic measurements of the optic nerve sheath diameter (ONSD) correlate with signs of increased ICP. The aim of this study is to compare the effect of pnemoperitoneum on intracranial pressure and cerebral oxygenation during laparoscopic surgery according to anesthesia agents, propofol based total intravenous anesthesia (TIVA group) and desflurane anesthesia (Des group).

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients (20-80 years of age) scheduled for laparoscopic cholecystectomy undergoing general anesthesia

Exclusion criteria

• Patients with previous history of neurologic disease, carotid disease, transient ischemic attack, ocular disease and ocular surgery

Trial design

0 participants in 2 patient groups

TIVA

Experimental group

Description:

2% Propofol (Fresofol®), Remifentanil 20mcg/cc (Ultiva®)

Treatment:

Drug: Propofol

Des

Active Comparator group

Description:

Desflurane (Suprane®), Remifentanil continuous infusion (20mcg/cc)

Treatment:

Drug: Desflurane