The Effect of Pneumoperitoneum Timing on Intracranial Pressure in Laparoscopy

Bagcilar Training and Research Hospital

Status: Completed

Conditions: Pneumoperitoneum; Intracranial Pressure Increase

Treatments: Procedure: Pneumoperitoneum Timing (Before Positioning); Procedure: Pneumoperitoneum Timing (After Positioning)

Study type: Interventional

Funder types: Other

Identifiers

NCT04224532

2019.10.103.072

Details and patient eligibility

About

Reverse Trendelenburg position has been shown to slightly reduce the intracranial pressure associated with pneumoperitoneum. However, there are no studies on the effect of the timing of reverse Trendelenburg position on intracranial pressure. This study will monitor the effect of reverse Trendelenburg position before or after pneumoperitoneum on intracranial pressure and regional cerebral oxygen saturation.

Full description

The literature includes studies that investigate the relationship of pneumoperitoneum and different positions with intracranial pressure during laparoscopy. Reverse Trendelenburg position has been shown to slightly reduce the intracranial pressure associated with pneumoperitoneum. However, there are no studies on the effect of the timing of reverse Trendelenburg position on intracranial pressure. This study will monitor the effect of reverse Trendelenburg position before or after pneumoperitoneum on intracranial pressure and regional cerebral oxygen saturation. Ultrasound guided measurement of the optic nerve sheath diameter as a non-invasive method will be used for measurement. The investigators believe reverse Trendelenburg position before pneumoperitoneum may prevent undesired sudden increases in intracranial pressure.

Enrollment: 79 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Undergoing laparoscopic cholecystectomy operation
• Age between 18-65
• ASA I-II
• BMI ≤ 35

Exclusion criteria

• Ophthalmologic disease and optic nerve pathology
• Increased intracranial pressure
• History of cerebrovascular disease

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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79 participants in 2 patient groups

Group P

Experimental group

Description:

Pneumoperitoneum is induced before reverse Trendelenburg position.

Treatment:

Procedure: Pneumoperitoneum Timing (Before Positioning)

Group RT

Experimental group

Description:

Pneumoperitoneum is induced after reverse Trendelenburg position.

Treatment:

Procedure: Pneumoperitoneum Timing (After Positioning)