The Effect of Pork With Modified Fat Composition and Berries on Plasma Fatty Acids and Fecal Compounds in Healthy Adults

University of Helsinki

Status: Completed

Conditions: Cardiovascular Diseases

Treatments: Dietary Supplement: Pork; Dietary Supplement: Modified pork; Dietary Supplement: Pork and berries

Study type: Interventional

Funder types: Other

Identifiers

NCT02469285

KarniMari-HY

Details and patient eligibility

About

High consumption of red meat is related to cardiovascular diseases. Red meat containing more unsaturated fat than normal red meat may have a beneficial impact on plasma lipid and fatty acid profile in humans. Furthermore, consumption of red meat and especially processed red meat is considered harmful to colon health. However, consumption of fruit and berries rich in antioxidants and flavonoids may provide protection when red meat is consumed.

The study aims to answer whether the fatty acid profile of pork when modified towards more unsaturated fat will affect plasma fatty acids and lipids in adult volunteers. The effects of pork with a modified fatty acid content is compared with conventional pork with lower unsaturated fat content. Fatty acid composition of pork is modified by altering the composition of animal feed.

The other arm of the study investigates the effects of consuming berries together with red meat on gut metabolism. The study focuses on how berries affect the formation of fecal compounds known to be related to high red meat consumption, such as N-nitroso compounds.

Enrollment: 65 patients

Sex: All

Ages: 20 to 68 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• diet includes meat

Exclusion criteria

• high consumption of fish (4 times per week)
• use of fish oil/ omega-3 oil capsules one month before the intervention
• hypercholesterolemia
• vegetarian, vegan

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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65 participants in 3 patient groups

Modified pork

Experimental group

Description:

Pork with modified fatty acid composition, more unsaturated fat. 160 g pork or pork products daily for 4 weeks, consumption of other red meat is prohibited

Treatment:

Dietary Supplement: Modified pork

Normal pork

Active Comparator group

Description:

Normal pork 160 g pork or pork products daily for 4 weeks, consumption of other red meat is prohibited

Treatment:

Dietary Supplement: Pork

Normal pork and berries

Experimental group

Description:

Normal pork and berries (strawberry, raspberry, wild blueberry, lingonberry, cloudberry, blackcurrant) 160 g pork or pork products daily for 4 weeks, consumption of other red meat is prohibited

Treatment:

Dietary Supplement: Pork and berries