The Effect of Positive End Expiratory Pressure on Central Venous Pressure Among Patients With Different Lung Compliance

Jingyuan,Xu

Status: Unknown

Conditions: Traumatic Brain Injury; ARDS; Sepsis

Treatments: Other: 5,10 and 15cmH2O positive end expiratory pressure

Study type: Interventional

Funder types: Other

Identifiers

NCT03341572

2017ZDSYLL094-P01

Details and patient eligibility

About

To observe the effect of PEEP on CVP among patients with different respiratory compliance

Full description

30 patients with mechanical ventilation and inserted central venous line will be entered. After gathering demographic data, patients undergone 5,10 and 15cmH2O PEEPs and the respective CVPs of the mentioned points will be recorded. According to the change of CVP, the patients will be divided into high response group and low response group, then comparing the lung compliance and thorax elastic resistance differences between the two groups.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients with mechanical ventilation and inserted central venous line

Exclusion criteria

1. The age is less than 18 years old or more than 80 years old；
2. Pregnant and lying-in woman；
3. Patients undergoing fluid resuscitation and the speed is more than 200ml/h；
4. Patients with norepinephrine dose are greater than 15 micro per minute；
5. Patients with pericarditis、pulmonary heart disease、right heart failure、atrial fibrillation；
6. Patients with COPD(endogenous PEEP is more than 2cmH2O)、tension pneumonthorax、acute episode asthma

Trial design

Primary purpose: Supportive Care

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

30 participants in 2 patient groups, including a placebo group

high response group

Experimental group

Description:

patients undergo 5,10 and 15cmH2O positive end expiratory pressure ,the change of central venous pressure is more than 2.5cmH2O

Treatment:

Other: 5,10 and 15cmH2O positive end expiratory pressure

low response group

Placebo Comparator group

Description:

the change of CVP is less than 2.5cmH2O

Treatment:

Other: 5,10 and 15cmH2O positive end expiratory pressure