The Effect of Post-extraction Collagen Sponge Application on Alveolar Osteitis

Riyadh Colleges of Dentistry and Pharmacy

Status and phase: Not yet enrolling; Phase 2

Conditions: Alveolar Osteitis

Treatments: Other: No collagen sponge application after surgical extraction of impacted 3rd molar; Other: Application of a collagen sponge after surgical extraction of impacted 3rd molar

Study type: Interventional

Funder types: Other

Identifiers

NCT05850650

REU

Details and patient eligibility

About

The goal of this randomized controlled trial is to compare pain, mouth opening, and alveolar osteitis following surgical extraction of bilateral symmetrical impacted lower third molars using two types of wound closures. Collagen plugs will be applied in the sockets of the study side followed by suture, while the controlled side will be sutured without a collagen plug. The study will include 40 patients aged between 18- 40 years old, medically fit (ASA1), who have bilateral symmetrical impacted lower third molars and visit the oral surgery clinics of King Saud Medical City for extraction. The main question is" Does intra-alveolar collagen application after surgical extraction of impacted lower third molars reduce the incidence of alveolar osteitis?

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Forty patients aged between 18- 40 years old, ASA1, who have bilateral symmetrical impacted lower third molars and visit the oral surgery clinics of King Saud Medical City for extraction.

Exclusion criteria

Uncontrolled systemic diseases, diabetes, bone diseases, smokers, epinephrine contraindications, pregnant women, breastfeeding women, and those who were using oral contraceptives.

Other exclusion criteria are the presence of acute infection and facial swelling, cystic lesions, and TMJ problems. Moreover, any surgical extraction that lasts more than 30 minutes +/- 5 minutes, or has been done without the whole standardized steps will be excluded.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

Controlled

Active Comparator group

Description:

The extraction socket will not receive a collagen sponge

Treatment:

Other: No collagen sponge application after surgical extraction of impacted 3rd molar

Collagen

Experimental group

Description:

The extraction socket will receive a collagen sponge

Treatment:

Other: Application of a collagen sponge after surgical extraction of impacted 3rd molar