The Effect of Prebiotics on the Microbiome in Irritable Bowel Syndrome Patients: The Diet and Microbiome Study

Queen's University

Status: Completed

Conditions: Irritable Bowel Syndrome

Treatments: Dietary Supplement: Factor Altered Diet

Study type: Interventional

Funder types: Other

Identifiers

NCT01829932

DMED-1443-11

Details and patient eligibility

About

Irritable bowel syndrome (IBS) is a chronic gastrointestinal illness of unknown cause whose symptoms include abdominal pain, bloating and altered bowel pattern. Diet has been shown to influence the bacteria gut interaction. Our aim is to determine if components of the diet affect IBS symptoms by changing the bacteria gut interaction. In particular, we will measure whether after being on a diet high or low on certain factors there is a change in the timing and amount of hydrogen and methane produced by bacteria digesting lactulose and on IBS symptom severity.

Enrollment: 30 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Meet Rome III criteria for IBS
• Willing to undergo dietary intervention

Exclusion criteria

• History of Gastric, Small Bowel or Colonic Surgery
• History of Inflammatory Bowel Disease
• Celiac Disease
• Unable to come off following medications: antibiotics, laxatives, narcotics, sedatives
• On a pre specified diet
• Pregnant

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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30 participants in 2 patient groups

High Factor Diet

Active Comparator group

Description:

Patients will be on a factor altered diet to see effects on their lactulose breath test and symptoms.

Treatment:

Dietary Supplement: Factor Altered Diet

Low Factor Diet

Active Comparator group

Description:

Patients will be on a factor altered diet to assess its effects on symptoms and lactulose breath test.

Treatment:

Dietary Supplement: Factor Altered Diet