The Effect of Prednisone on Physical Exercise in COPD Patients (COPDpred)

Bispebjerg Hospital

Status and phase: Completed; Phase 4

Conditions: Exercise Performance in Copd Patients

Treatments: Drug: prednisone

Study type: Interventional

Funder types: Other

Identifiers

NCT01978665

2012-004503-13 (EudraCT Number)

Details and patient eligibility

About

The objective of this study is to investigate if there is an effect on exercise performance og of the anti inflammatory drugs prednisone and solu-medrol in patints with chronic obstructive pulmonary disease(COPD)

Full description

RCT study with 4 days of steroid

Enrollment: 14 patients

Sex: Male

Ages: 40 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:FEV1< 60% FEV1/FVC ratio <70 %

• able to use a ergometer bike

Exclusion Criteria: Haemodynamicaly unstable heart conditions

• exacerbations before 6 week entry of the study exacerbation during the study period treatment with beta blockers malignancy the last 5 years allergi toward IMP

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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14 participants in 3 patient groups, including a placebo group

prednisone and Solumedrol

Placebo Comparator group

Description:

placebo arm versus prednisone

Treatment:

Drug: prednisone

solumedrol

Placebo Comparator group

Description:

placebo versus solu medrol

Treatment:

Drug: prednisone

placebo

Other group

Description:

measurement of fitness

Treatment:

Drug: prednisone