The Effect of Pregabalin and Dexamethasone on Acute and Chronic Pain After Lumbar Spinal Surgery

Yonsei University

Status: Completed

Conditions: Pain

Treatments: Drug: Pregabalin; Drug: placebo; Drug: dexamethasone

Study type: Interventional

Funder types: Other

Identifiers

NCT01168531

4-2009-0506

Details and patient eligibility

About

Multimodal analgesia may be important for optimal postoperative pain treatment and facilitation of early mobilization and recovery. This study investigated the analgesic effect of pregabalin and dexamethasone in patients undergoing lumbar spinal surgery.

Enrollment: 108 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients scheduled for lumbar spinal surgery, aged 20 to 70 years, with a body mass index (BMI) from 18 to 32 and an American Society of Anesthesiologists (ASA)physical status classification of I-II were eligible for the study.

Exclusion criteria

• allergy to any drugs in the study
• alcohol and/or drug abuse
• treatment with antacids or antidepressants
• a history of diabetes or epilepsy
• a daily intake of analgesics or an intake of any analgesic within 24 h before surgery
• treatment with systemic glucocorticoids within 4 weeks before surgery
• known impaired hepatic and renal function.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Double Blind

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108 participants in 3 patient groups, including a placebo group

placebo arm

Placebo Comparator group

Treatment:

Drug: placebo

pregabalin arm

Active Comparator group

Treatment:

Drug: Pregabalin

dexamethasone with pregabalin arm

Experimental group

Treatment:

Drug: dexamethasone