The Effect of Pregabalin on Pain of Propofol Injection

Kyungpook National University

Status: Completed

Conditions: Pain

Treatments: Drug: propofol; Drug: Pregabalin; Drug: Lidocaine

Study type: Interventional

Funder types: Other

Identifiers

NCT02668094

2015-03-037-001

Details and patient eligibility

About

Pain is a common side effect of propofol injection. The purpose of this study was to compare the efficacy of pregabalin and lidocaine in reducing propofol injection pain.

Full description

In a randomized, double blind, prospective trial, 120 patients were allocated to one of three groups (each n=40) receiving intravenous lidocaine 40mg (group L), oral pregabalin 75 mg (group LP), and oral pregabalin 150 mg (group HP) as pretreatment, followed by injection of 25% of 2 mg/kg propofol. Pain was assessed by a four point scale (0=no, 1=mild, 2=moderate, 3=severe pain).

Enrollment: 120 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient underwent elective dental surgery.

Exclusion criteria

• Patient with a history of adverse response to lidocaine or pregabalin,
• Patient with cardiovascular or respiratory disease,
• Patient who takes any sedatives, analgesics, or anticonvulsants within 24 hours before surgery.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

---

120 participants in 3 patient groups

Group L

Active Comparator group

Description:

Lidocaine 40mg was given intravenously before injection of propofol

Treatment:

Drug: propofol

Drug: Lidocaine

Group LP

Active Comparator group

Description:

Pregabalin 75 mg was given orally 2 hour before surgery

Treatment:

Drug: propofol

Drug: Pregabalin

Group HP

Active Comparator group

Description:

Pregabalin 150 mg was given orally 2 hour before surgery

Treatment:

Drug: propofol

Drug: Pregabalin