Effect of Pregabalin on Shoulder Pain in Patients With Central Sensitization After Arthroscopic Rotator Cuff Repair

The Catholic University of Korea

Status and phase

Not yet enrolling

Phase 4

Conditions

Neuropathic Pain

Central Sensitisation

Rotator Cuff Tears

Treatments

Drug: Pregabalin

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT06367998

PC24MISV0017

Details and patient eligibility

About

This study aims to investigate the effects of Pregabalin intake on shoulder pain management in patients with central sensitization undergoing arthroscopic rotator cuff repair. Although Pregabalin is known to be effective in controlling pain after shoulder arthroscopy, research on its efficacy in pain management for patients with central sensitization is scarce. Utilizing a list that identifies central sensitization, this study will explore whether Pregabalin can reduce postoperative pain in these patients and potentially improve joint mobility, emotional, and physical functioning. A prospective randomized study is planned, with inclusion criteria set for patients aged between 19 and 70 who have undergone arthroscopic rotator cuff repair.

The study will compare clinical outcomes up to one year postoperatively between two groups of 38 patients each. The case group will receive standard postoperative medications (NSAIDs) plus Pregabalin oral intake from the day before surgery to six weeks postoperatively, while the control group will receive only the standard postoperative medications without Pregabalin.

Enrollment

76 estimated patients

Sex

All

Ages

20 to 69 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age over 19 to under 70
Underwent arthroscopic rotator cuff repair due to a tear of the rotator cuff.
Clinical diagnosis of myofascial pain syndrome
Central sensitization (Central Sensitization Inventory (CSI) score of 40 or above).

Exclusion criteria

Previous history of Pregabalin prescription
Hypersensitivity reactions or severe complications after taking Pregabalin.
Diagnosed with and are being treated for psychiatric disorders
Localized infection, sepsis, or previous neurological abnormalities
Uncontrolled hypertension (evidenced by a resting blood pressure of more than 100 mmHg)
Liver function abnormalities (aspartate aminotransferase or alanine aminotransferase >60 IU/litre).
major cardiovascular diseases or renal impairments