The Effect of Pregabalin on the Spinal Anesthesia

Kyungpook National University

Status: Completed

Conditions: Block

Treatments: Drug: Placebo; Drug: Pregabalin

Study type: Interventional

Funder types: Other

Identifiers

NCT02690506

2014-05-027

Details and patient eligibility

About

Pregabalin, an anticonvulsant is widely used for treatment of neuropathic pain. Recently, it was reported that premedication of pregabalin before general anesthesia is effective to reduce postoperative pain. Up to date, there is no study about the effect of premedication of pregabalin on the spinal anesthesia. Therefore, in this study, investigators investigate the effect of premedication of pregabalin on the spinal anesthesia.

Full description

In this study, investigators investigate the effect of premedication of pregabaline 150 mg on the spinal anesthesia. Two hours before spinal anesthesia, placebo pill was administered to patients in the group C and pregabalin 150 mg was administered to patients in the group P, respectively. Time for the onset of blockade, cephalad level of analgesia and duration of analgesia were measured.

Enrollment: 44 patients

Sex: All

Ages: 19 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients of American Society of Anaesthesiologists Grades I and II

Exclusion criteria

• Patients with infection at the puncture site, coagulopathy, having true hypersensitivity to drugs used, diabetes and hypertension, psychiatric and neurological diseases

Trial design

44 participants in 2 patient groups, including a placebo group

Group C

Placebo Comparator group

Description:

Oral placebo pill was administered 2 hours before anesthesia

Treatment:

Drug: Placebo

Group P

Active Comparator group

Description:

Oral pregabalin 150 mg was administered 2 hours before anesthesia

Treatment:

Drug: Pregabalin