The Effect of Preoperative NLR Level on Epidural Analgesia Application in Thoracotomy

Karadeniz Technical University

Status: Completed

Conditions: C23.550.767.700; C23.550.470

Treatments: Diagnostic Test: Neutrophil Lynphosite ratio

Study type: Observational

Funder types: Other

Identifiers

NCT05209958

2020/66

Details and patient eligibility

About

The aim of this study is to investigate the relationship of preoperative Neutrophil/Lymphocyte Ratio (NLR) with postoperative pain and the effect of preoperative NLR level on timing of epidural analgesia in thoracotomy.

Full description

The study was conducted prospectively in 60 patients aged 18-75 years, ASA I-III, who underwent thoracotomy. The patients were divided into 2 groups as NLR level above 2 (Group A) (n:32) and NLR level below 2 (Group B) (n:28). Each group was divided into subgroups with equal numbers of Prempative analgesia group and control group. Local anesthetic was administered to the preemptive analgesia group (Group P) 20 minutes before the surgical incision through the epidural catheter, and to the control group (Group K) 20 minutes before the patient was awakened from the epidural catheter. NRS levels and additional analgesia needs were recorded at 2, 4, 8, 12 and 24 hours postoperatively.

Enrollment: 60 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient graded as American Society of Anesthesiologist (ASA) physical status, I, II or III
• Patient subjected to thoracotomy operation

Exclusion criteria

Patient having morbid obesity,

• Patient having renal failure,
• Patient having hepatic failure,
• Patient having neuropsychiatric disease,
• Patient allergy to the study drugs

Trial design

60 participants in 2 patient groups

Group A

Description:

Patients with NLR level below 2

Treatment:

Diagnostic Test: Neutrophil Lynphosite ratio

Group B

Description:

Patients with NLR level equal to or above 2

Treatment:

Diagnostic Test: Neutrophil Lynphosite ratio